The contestants leave Miami for Quito, Ecuador. The morning after they arrive, they head to Cotopaxi National Park and face a Detour. The racers can choose either Wrangle It, in which they must help lasso a wild horse and groom it, or Recover It, in which they must search a field for three items that are missing from a historical uniform. The first team to arrive has time on its side, but the chosen task is more difficult than it initially seemed. Meanwhile, some of the other teams have problems of their own as they struggle to find the national park.

Teams leave Ecuador and fly to Santiago, Chile. Two teams snag an earlier flight, but they don’t get the advantage they hoped to gain. Upon arrival in Santiago, the racers head to a copper-mining company for their next clue, a Roadblock. Each participant must search the board room for letters of the alphabet and unscramble them. Teams then fly to the city of Calama where they face a Detour. They can choose either By Hand, in which they must secure a tire to a truck, or By Machine, in which they must transfer gravel using a front loader. After completion, the racers drive to the Valley of the Dead to find the Pit Stop.

The racers must leave the city of Calama and fly to Puerto Montt, Chile. The animosity toward Rob and Amber continues to grow, but they are not the only source of frustration. The desire to get on an earlier fight sparks many arguments in the airport. When the teams land, there is a Roadblock waiting for them. They must remove fish from a tank in order to receive their next clue. After completion, the racers find a Detour. They can choose between Vertical Limit, in which they must perform a forty-foot rock climb, and River Wild, in which they must take a boat through a white water rafting course. One team makes a huge mistake that might cost them the race. Finally, it’s off to the pit stop at Playa PetrohuA©.

Teams now fly to the city of Punta Arenas, Chile. Once they find the shipwreck, they will discover their next clue. In this Detour, teams can choose between Navigate it, in which they must use a map of Punta Arenas to ultimately find the Nautilus building, and Sign It, in which they must use a map of Magellan’s voyage to build a traditional local sign post. Problems early on may tarnish Rob and Amber’s pristine record. After completion, contestants fly to Ushuaia, Argentina where a Roadblock is waiting for them. In this task, each chosen member must look through numerous envelopes and find a letter addressed to their team. Once the letter is read completely, they receive their final destination.

Teams head to Maputo, Mozambique where they must drive, via taxi, to the base of Martial Mountain chain. There, they must ride the chair lift and hike to Martial Glacier. On the Glacier, they will have to use an avalance beacon to find their next clue. At the Roadblock, one team member must use a rat to find a marker near a deactivated mine. In the end, one team may be eliminated.

Teams travel to Marhsall Mountain where they must hike to find their next clue. The clue leads them to Naputo, Mozambique where they must use trained rats to complete their Roadblock.

Teams leave Zanzibar and fly to Warsaw, Poland. In Warsaw, the teams must complete a Detour, Skill or Might, and receive a clue leading them to the Jan III Sobieski Lozenki statue. In the end, one team may be eliminated.

In the 11th season finale, teams leave the Jan III Sobieski Lozenki statue in Warsaw and travel to the Auschwitz concentration camp in Birkenau. Each team member must light a candle in remembrance of the Holocaust victims. From there, teams must pair up with another team in the Fast Forward. From there, they race to the final pit stop.

The teams leave the Pit Stop at the Pieskowa Ska?a castle in Krakow, Poland for Kuala Lumpur, Malaysia. On their arrival they will head off to Batu Caves. Frustrations build over the Detour task, leaving a pair of teams to switch tasks. Upon completion they will head to a newspaper in Taman Sri Hartamas. The locals must assist the teams on a stressful and tiring Roadblock. One team falls far behind after missing a flight connection to the final Pit Stop.

From the Pit Stop at the Mansion on the Hill in Kuala Lumpur, Malaysia the teams receive the next clue instructing them to fly to Hong Kong. While in Hong Kong the teams will travel to a laundry. The first place team finds themselves strapped for cash. Meanwhile, the teams must complete a demanding climbing assignment and one team will take the wrong ferry. After kicking down some doors at the Roadblock, the teams head to the final Pit Stop at the Hong Kong Jockey Club.

From the Pit Stop at the Hong Kong Jockey Club the teams travel forty miles away to Macau, aboard turbojet ferries. Upon the arrival at the Macau Tower, one team makes a plan to raise funds to help ease their financial troubles. The Roadblock consists of the highest ever jump in the shows history. Once this task is completed the contestants will board a taxi to Lou Lim Ioc Garden. There they will be tested on their ability to pay attention to details or use their navigational skills. The teams must drive a mini-moke to the final Pit Stop.

Teams will take off from Triho de Taipa Pequena 2000 and head to Anderson Air Force base near the island of Guam. At the base, each team will enter the control tower where they will receive their clue of a detour. They can choose between cleaning or dare to participate in some high flying. The Roadblock task finds the teams testing their search and rescue skills. The final elimination before the finals will take place at final Pit Stop at Fort Soledad.

The final three contestants are set to battle over the $1,000,000 grand prize. From their pit stop in Guam, the players are instructed to fly to Honolulu, Hawaii, where they will be testing their skills both on land and on the sea. A final flight to San Francisco's Botanical Gardens will be the site of the final destination.